Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 21640343
Gene Name IHH
Condition Endometriosis
Association Associated
Population size 56
Population details 56 (26 healthy volunteers, 30 women with endometriosis)
Sex Female
Infertility type Female infertility
Associated genes Hedgehog protein
Other associated phenotypes Endometriosis
Endometrial Indian hedgehog expression is decreased in women with endometriosis.

Fertil Steril. 2011 Jun 30;95(8):2738-41.e1-3. doi:

Smith, Kathryn| Alnifaidy, Redab| Wei, Qingxiang| Nieman, Lynnette K

Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1109, USA.

Nuclear and cytoplasmic endometrial expression of Indian hedgehog increased from the late proliferative to mid and late secretory phases in 26 healthy volunteers compared with 30 women with endometriosis. The abnormal expression of Indian hedgehog protein in women with endometriosis suggests a resistance to P action.

Mesh Terms: Adult| Biopsy| Case-Control Studies| Cell Nucleus/metabolism| Cytoplasm/metabolism| Down-Regulation| Endometriosis/*metabolism| Endometrium/*metabolism| Female| Hedgehog Proteins/*metabolism| Humans| Immunohistochemistry| Laparoscopy| Marylan